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Overgevoeligheidsreacties, de kans hierop neemt toe na herhaalde i.v.-toediening. Thiamine (vitamine B1) is in de vorm van thiamine-pyrofosfaat een Parenteral administration (intermittent infusion and IV push) of thiamine has minimal safety concerns with a few allergic reactions reported, however; it has been associated with uncommon cases of angioneurotic edema, anaphylactic shock, and cardiac arrest. 6,7 Current literature suggests thiamine up to 250 mg is most likely safe to be administrated as an IV push. This should not preclude the use of parenteral thiamine in patients where this route of administration is required, particularly in patients at risk of Wernicke-Korsakoff syndrome where treatment with thiamine is essential; Intravenous administration should be by infusion over 30 minutes; The most common adverse reaction to parenteral thiamine administration is an injection site reaction. Pain, induration, and tenderness after IM injection can occur. Patients receiving IV thiamine may experience transient burning or pain immediately after injection into the IV site or IV line. setlakin birth control side effects CONCLUSION: Administration of IV push thiamine was not associated with any anaphylactic event and had a low incidence of IV site reactions. IV push thiamine in doses up to 250 mg appeared to be safe. There may be an indication for its safe administration with doses up to 500 mg, although more research is needed.

Thiamine is completely and rapidly absorbed after IM and IV administration. In chronic alcohol mis-users, malnutrition can reduce intestinal thiamine absorption by ~70%, decreasing serum levels from 30 to 98% below the lower level established for normal subjects. In two patients, intravenous thiamine had been administered before blood was drawn and the thiamine level returned abnormally high ( nmol/l). The median baseline magnesium level was 1.8 mg/dl, and seven patients had magnesium replaced during their hospitalization (median magnesium level was 1.8 in magnesium-treated patients and 1.85 There is a small, but definite risk of anaphylaxis with parenteral thiamine, specifically with intravenous administration (1/250,000 intravenous injections). Diluting thiamine in 50 100 mg normal saline for infusion may reduce the risk.

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